Pathophysiology of Sickle cell anemia
In the pathophysiology of Sickle cell anemia or Sickle cell disease (SCD), we learn that it is a systemic disorder caused by a mutation in the gene encoding the β chain of hemoglobin. This mutation leads to the production of sickle hemoglobin HbS. Sickled red blood cells were first observed in 1910 by JB Herrick
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