Antianemic potentials of Theobroma cacao L. stem bark for 2017

ANTIANAEMIC POTENTIALS OF THEOBROMA CACAO L. STEM BARK IN PHENYLHDRAZINE TREATED FEMALE ALBINO WISTAR RATS

 

 

BY

UCHEGBU CHIBUEE

PHY/T/12/033

 

DEPARTMENT OF HUMAN PHSIOLOGY, FACULTY OF BASIC MEDICAL SCIENCES, MADONNA UNVERSITY, ELELE CAMPUS, RIVERS STATE, NIGERIA.

 

 

 

SEPTEMBER, 2017.

 

 

ANTIANAEMIC POTENTIALS OF THEOBROMA CACAO L. STEM BARK IN PHENYLHDRAZINE TREATED FEMALE ALBINO WISTAR RATS

 

 

BY

UCHEGBU CHIBUEZE

PHY/T/12/033

 

A PROJECT SUBMITTED TO THE DEPARTMENT OF PHSIOLOGY, FACULTY OF BASIC MEDICAL SCIENCES, MADONNA UNVERSITY, ELELE CAMPUS, RIVERS STATE, NIGERIA

 

 

IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF BACHELOR OF SCIENCE (B.SC.HONS) DEGREE IN PHSIOLOGY

 

 

SEPTEMBER, 2017.

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ABSTRACT

Previous studies indicated that the stem bark of Theobroma cacao L. is enrinched with minerals like phosphorus, sodium, calcium, magnesium and vitamins. The present study investigated the effect of higher doses of aqueous extracts of Theobroma cacao L. stem bark on some haematological parameters (White Blood Cell, Red Blood Cell indices, hemoglogin concentration, hematocrit and platelet) of normal and Phenylhydrazine-induced anaemic albino wistar rats.  Forty female albino wistar rats weighing 130-200g were randomly grouped into 8 groups of 5 rats each. Group 1 (normal control) were fed with standard feed and water only, group 2 (positive control) was induced with anaemia without treatment, groups 3, 4 and 5 were induced with anaemia and treated with 200mg/kg,500mg/kg and 800mg/kg b. wt.,  of Theobromacacao L. stem bark extract respectively. Groups 6, 7 and 8 were normal rats given 1000mg/kg,3000mg/kg and 5000mg/kg b. wt. of the extract respectively for 21 days. Phenylhydrazine was used to induce anaemia intraperitoneal at the dosage of 60mg/kg body weight for two days. The result obtained after the experiment showed a significant increase (p<0.001); (p<0.05) in the Red Blood Cell, and also in the White Blood Cell a significant increase (p<0.001) was observed, the Hemoglobin concentration and hematocrit equally showed a significant increase (p<0.001) both in anaemic and normal groups. The increases suggest that the aqueous extracts of the cocoa stem bark possesses haematinic properties which could be helpful substitutes in cases of blood shortage or other conditions which places high demand on the blood forming system of the body.

 

 

 

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ANTIANAEMIC POTENTIALS OF THEOBROMA CACAO STEM BARK

 

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